TB Database: an integrated platform for tb drug discovery
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Announcements

July 2008:

  • We are pleased to make available the annotated Mycobacterium marinum genome sequence as reported in Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. M. marinum, a pathogen of fish and amphibians, is a close relative of M. tuberculosis, the etiologic agent of tuberculosis in humans. Analysis of the M. marinum genome reveals genome downsizing and lateral gene transfer in M. tuberculosis that allowed it to become a specialized pathogen of humans and primates, and facilitates better understanding of tuberculosis disease.
  • We recently made enhancements to the quick search function to find Rfam annotations, which allow identification of likely functional RNAs, for example riboswitches.
    Rfam Search results

    • June 2008: We are pleased to announce that TBDB now holds data from a publication by Rustad et al. titled "The enduring hypoxic response of Mycobacterium tuberculosis". The DosR regulon is known to play a primary role in survival of hypoxia induced bacteriostasis in Mycobacterium tuberculosis. Based on the results presented in this paper the authors suggest a reassessment of the role of DosR and the initial hypoxic response in MTB physiology.

    May 2008:
    TubercuList provides a complete dataset of DNA and protein sequences derived from the paradigm strain M. tuberculosis H37Rv, linked to the relevant annotations and functional assignments, using various criteria (gene names, location, keywords, etc.). Now TBDB provides direct links to TubercuList from 'External Links' section of a Gene Detail page. For an example of the new Gene Detail page with a link to TubercuList, visit     RV2429.

    February 2008: We are happy to announce that TBDB provides links from gene pages to the Tuberculosis Structural Genomics Consortium (TBSGC). Using this resource, you can find stuctural information as well as images for TB proteins.

    webtb

    Stanford School of Medicine
    Broad Institute

    About the TB Database Project

    Tuberculosis (TB) is a public health challenge of paramount importance. Control of TB will require a multifaceted approach integrating efficient public health interventions with the discovery and use of new vaccines and drugs. TBDatabase (TBDB) makes available the tools and resources available at the Stanford Microarray Database and the Broad Institute.

    Anyone is welcome to access the published data available on the TBDB site without signing in. Some data in TBDB are unpublished and can therefore only be accessed by the authors and their collaborators after they sign in. The "Access Polices" page provides more information about TBDB accounts.

    A grant from the Bill & Melinda Gates Foundation has enabled us to create an integrated software platform for tuberculosis drug discovery and research. Learn more >

    TB Resources